Project IV (MATH4072) 2023-24


Spiral waves in the heart

Paul Sutcliffe

Description

A heartbeat involves a wave of electrical activity that travels through cardiac tissue and can be recorded in an electrocardiogram. The underlying cause of some arrhythmias, such as ventricular tachycardia and ventricular fibrillation, is the formation of spiral waves that disrupt the normal behaviour of the heart. Spiral waves have their own period and can overwhelm the natural pacemaker of the heart.

A simple mathematical model of electrical activity in the heart is the FitzHugh-Nagumo partial differential equation. This is a reaction-diffusion equation with spiral wave solutions.
A spiral wave solution of the FitzHugh-Nagumo equation.
The project involves learning about the FitzHugh-Nagumo model for cardiac dynamics and writing some computer programmes in python to compute some of its solutions, including spiral waves.

Prerequisites

None. However, some parts of any of the following modules could be helpful: Mathematical Biology III, Dynamical Systems III, Numerical Analysis II, Mathematical Modelling II.

Resources

There are several webpages that discuss this topic.
Some examples can be found at the virtual heart and spiral waves break hearts.
Relevant books in the library include:
The geometry of biological time by Winfree and Mathematical biology by Murray

email: Paul Sutcliffe