Seminars in Mathematical Sciences

Seminars in the next week
Oct 27 (Mon)

13:00 MCS2068 StatBen Swallow (University of St. Andrews): Some recent developments in Bayesian Gaussian processes for non-linear systems in computational biology

Gaussian processes are a widely-used statistical tool for conducting non-parametric inference in computational biology. In this talk, I will outline a couple of recent projects where we have developed Bayesian computational approaches to approximating complex, non-linear dynamics in systems biology and infectious disease epidemiology, taking advantage of the analytical tractability of Gaussian processes. Firstly, I will discuss an extension to the linear noise approximation in high-dimensional, non-linear systems of chemical kinetics, embedded within a Bayesian MCMC framework for accurate parameter inference and uncertainty quantification. The approach is applied to cell-signalling and circadian clock systems of up to 20 variables. Secondly, I will describe an approach to modelling spatio-temporally indexed data on notifiable diseases in England, using software packages that can interact with tensorflow probability. The approach enables a relatively straightforward implementation on GPUs with significant speed increase over standard CPU calculations, whilst still allowing asymptotically exact inference and uncertainty quantification. Long-term temporal accuracy is maintained in both approaches.

Venue: MCS2068

Oct 28 (Tue)

13:00 MCS2068 APDEMarius Tiba (King's College London): Stability of Geometric and Functional Inequalities

The Brunn-Minkowski inequality is a fundamental result in convex geometry and analysis, closely related to the isoperimetric inequality. It states that for (open) sets \(A\) and \(B\) in \(\mathbb{R}^d\), we have \[|A+B|^{1/d} \geq |A|^{1/d}+|B|^{1/d}.\] Here \(A+B={x+y : x \in A, y \in B}.\) Equality holds if and only if \(A\) and \(B\) are homothetic and convex sets in \(\mathbb{R}^d\). The Prekopa-Leindler inequality is a functional generalization of the Brunn-Minkowski inequality with important applications to high dimensional probability theory. If \(t \in (0,1) \) and \(f,g,h : \mathbb{R}^d \to \mathbb{R}_+\) are continuous functions with bounded support such that \[h(z) = \sup_{z = tx + (1-t)y} f^t(x) g^{1-t}(y),\] then \[\int h dx \geq \left(\int f dx\right)^t \left(\int g dx\right)^{1-t}.\] Equality holds if and only if \(f\) and \(g\) are homothetic (i.e. \(f=ag(x+b) \)) and log-concave (i.e. \(\log(f)\) is concave). The Borell-Brascamp-Lieb inequality is a strengthening of the Prekopa-Leindler inequality, replacing the geometric mean with other means.

The stability of these inequalities has been intensely studied lately. The stability of the Brunn-Minkowski inequality states that if we are close to equality, then \(A\) and \(B\) must be close to being homothetic and convex. Similarly, the stability of the Prekopa-Leindler and Borell-Brascamp-Lieb inequalities states that if we are close to equality, then \(f\) and \(g\) must be close to being homothetic and concave. In this talk, we present sharp stability results for the Brunn-Minkowski, Prekopa-Leindler and Borell-Brascamp-Lieb inequalities, establishing the exact dependency between the two notions of closeness, thus concluding a long line of research on these problems.

This talk is based on joint work with Alessio Figalli and Peter van Hintum.

Venue: MCS2068

13:10 MCS3052 E&PLitka Milian (Durham (Chemistry)): Listening to Student Voices: Disability and Inclusion in STEM

What does it really feel like to study chemistry at Durham as a disabled student? In this session, we will share insights from interviews with disabled students in the Chemistry Department, aiming to uncover the reasons behind the Awarding Gap in academic outcomes between disabled and non-disabled students. Through open conversations, students described barriers they face, sometimes as obvious as struggling to get into a lecture room, sometimes as subtle as feeling left out of group activities or not knowing where to find help. One student captured the frustration many feel, saying, “Sometimes it feels like the system wasn’t designed for people like me.” Another highlighted the problem of low expectations: “People often assume I need help with everything, but what I really need is for the environment to be accessible from the start.” These stories show that both attitudes and practical support need to change. Our project is a partnership between staff and student interns, who bring fresh perspectives and energy to the work. They have helped shape our questions, analyse the interviews, and will join us in presenting what we’ve learned. This collaborative approach reflects the principle of active pedagogy, where students are partners in shaping their own learning experience. We are still working on this project and are using what we’ve learned to write recommendations for future improvements. Our aim is to create more opportunities for students to share feedback, help shape solutions, and feel truly represented. By listening to student voices and acting on their ideas, we are putting inclusive learning design into practice, building a Chemistry Department and a STEM community where diversity is celebrated and every student has the chance to thrive, creating meaningful change.

Venue: MCS3052

Online: https://teams.microsoft.com/l/meetup-join/19%3ameeting_ZGQ3NDg0YzgtNTJiNi00MzVjLWFhYTAtYjc5N2IxOTc2YTQx%40thread.v2/0?context=%7b%22Tid%22%3a%227250d88b-4b68-4529-be44-d59a2d8a6f94%22%2c%22Oid%22%3a%226cb8930b-1559-4659-8c60-d0b762855115%22%7d

14:00 MCS2068 ASGVictoria Schleis (Durham University): General linear monoids over hyperfields

After a gentle introduction to hyperfields and their utility in combinatorics and combinatorial algebraic geometry, I will introduce their general linear monoids. This talk is based on joint work in progress with Yifan Guo.

Venue: MCS2068

Oct 29 (Wed)

15:00 MCS2050 A&CTim Adamo (University of Edinburgh): Scattering on self-dual black holes

Tree-level graviton scattering amplitudes provide an on-shell model for wave-wave scattering in general relativity, but computing them with traditional perturbative methods is hard due to the non-polynomial nature of the Einstein-Hilbert action. This is particularly true for graviton scattering in curved spacetimes, like black holes, which remains an extremely difficult problem. I will discuss a toy model of this problem: graviton scattering on a self-dual black hole (in particular, a self-dual Taub-NUT metric). This lets us bring powerful integrability methods to bear while still exhibiting the non-linear and non-perturbative hallmarks of 'real world' graviton scattering on black holes. Remarkably, in this setting it is possible to obtain explicit formulae for graviton scattering amplitudes which are exact in the background.

Venue: MCS2050

Oct 30 (Thu)

13:00 MCS2068 G&TJohn Parker (Durham University): Real hyperbolic on the outside, complex hyperbolic on the inside (2)

The title of the talk is the title of a paper by Richard Schwartz (Inventiones 2003) where he constructs a complex hyperbolic orbifold whose boundary is homeomorphic to a closed real hyperbolic three-manifold. The fundamental group of the orbifold is an index two subgroup of a group generated by three reflections where certain products of the reflections have particular finite orders. The proof is by way of an explicit construction of a fundamental polyhedron. In these talks I will discuss a joint project with Yohei Komori and Makoto Sakuma where we take the first step to generalise Schwartz’s construction. Namely, we give a topological construction of a candidate fundamental domain, and thereby we are able to describe the topology of the boundary manifold explicitly in terms of the finite orders of the products of reflections. In particular, we are able to topologically identify Schwartz’s boundary manifold.

Venue: MCS2068

14:00 MCS2068 ProbJulie Tourniaire (Laboratoire de Mathématiques, Université de Franche-Comté): Stochastic neutral fractions and the effective population size

Population genetics aims to explain observed genetic diversity through past evolutionary forces. In the neutral setting, i.e., in the absence of natural selection and ecological constraints, diversity arises solely from demographic fluctuations. In this simplified framework, the allelic composition of a population converges, in the large-population limit, to the Wright–Fisher diffusion.

This Wright–Fisher model is a purely genetic model, and a key question is how ecological constraints (such as population structure) may influence genetic composition. In this context, the ‘effective population size’, defined as the size of a Wright–Fisher population experiencing the same level of genetic drift as the population under study, plays a central role.

In this talk, I will introduce a stochastic differential equation with an infinite decomposability property to model the dynamics of general structured populations. This property allows the population to be decomposed into an arbitrary number of neutral allelic components (or fractions). When demographic fluctuations are small, a fast–slow principle yields a general expression for the effective population size in structured settings.

This is joint work with R. Forien, E. Schertzer, and Z. Talyigas

Venue: MCS2068

Oct 31 (Fri)

13:00 MCS0001 HEPMMax Velásquez Cotini Hutt (Imperial College London): Non-invertible Symmetries of 2d Non-Linear Sigma Models

Global symmetries can be generalised to transformations generated by topological operators, including cases in which this operator does not have an inverse. A family of such topological operators are related to dualities via the procedure of half-space gauging. I will discuss the construction of non-invertible defects based on T-duality in two dimensions, generalising the well-known case of the free compact boson to any Non-Linear Sigma Model with Wess-Zumino term which is T-dualisable. I will discuss how these symmetries can be used to constrain renormalisation group flows, and their fate in String Theory.

Venue: MCS0001

Nov 03 (Mon)

13:00 MCS2068 StatSam Livingstone (UCL):

Venue: MCS2068


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Upcoming Seminars by Series

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• Amplitudes and Correlators

Contact: arthur.lipstein@durham.ac.uk

Oct 29 15:00 Tim Adamo (University of Edinburgh): Scattering on self-dual black holes

Tree-level graviton scattering amplitudes provide an on-shell model for wave-wave scattering in general relativity, but computing them with traditional perturbative methods is hard due to the non-polynomial nature of the Einstein-Hilbert action. This is particularly true for graviton scattering in curved spacetimes, like black holes, which remains an extremely difficult problem. I will discuss a toy model of this problem: graviton scattering on a self-dual black hole (in particular, a self-dual Taub-NUT metric). This lets us bring powerful integrability methods to bear while still exhibiting the non-linear and non-perturbative hallmarks of 'real world' graviton scattering on black holes. Remarkably, in this setting it is possible to obtain explicit formulae for graviton scattering amplitudes which are exact in the background.

Venue: MCS2050

• Analysis and PDE

Usual Venue: MCS2068

Contact: yohance.a.osborne@durham.ac.uk

Oct 28 13:00 Marius Tiba (King's College London): Stability of Geometric and Functional Inequalities

The Brunn-Minkowski inequality is a fundamental result in convex geometry and analysis, closely related to the isoperimetric inequality. It states that for (open) sets \(A\) and \(B\) in \(\mathbb{R}^d\), we have \[|A+B|^{1/d} \geq |A|^{1/d}+|B|^{1/d}.\] Here \(A+B={x+y : x \in A, y \in B}.\) Equality holds if and only if \(A\) and \(B\) are homothetic and convex sets in \(\mathbb{R}^d\). The Prekopa-Leindler inequality is a functional generalization of the Brunn-Minkowski inequality with important applications to high dimensional probability theory. If \(t \in (0,1) \) and \(f,g,h : \mathbb{R}^d \to \mathbb{R}_+\) are continuous functions with bounded support such that \[h(z) = \sup_{z = tx + (1-t)y} f^t(x) g^{1-t}(y),\] then \[\int h dx \geq \left(\int f dx\right)^t \left(\int g dx\right)^{1-t}.\] Equality holds if and only if \(f\) and \(g\) are homothetic (i.e. \(f=ag(x+b) \)) and log-concave (i.e. \(\log(f)\) is concave). The Borell-Brascamp-Lieb inequality is a strengthening of the Prekopa-Leindler inequality, replacing the geometric mean with other means.

The stability of these inequalities has been intensely studied lately. The stability of the Brunn-Minkowski inequality states that if we are close to equality, then \(A\) and \(B\) must be close to being homothetic and convex. Similarly, the stability of the Prekopa-Leindler and Borell-Brascamp-Lieb inequalities states that if we are close to equality, then \(f\) and \(g\) must be close to being homothetic and concave. In this talk, we present sharp stability results for the Brunn-Minkowski, Prekopa-Leindler and Borell-Brascamp-Lieb inequalities, establishing the exact dependency between the two notions of closeness, thus concluding a long line of research on these problems.

This talk is based on joint work with Alessio Figalli and Peter van Hintum.

Venue: MCS2068

• Applied Mathematics

Usual Venue: MCS3070

Contact: andrew.krause@durham.ac.uk

No upcoming seminars have been scheduled (not unusual outside term time).

• Arithmetic Study Group

Usual Venue: MCS2068

Contact: herbert.gangl@durham.ac.uk

Oct 28 14:00 Victoria Schleis (Durham University): General linear monoids over hyperfields

After a gentle introduction to hyperfields and their utility in combinatorics and combinatorial algebraic geometry, I will introduce their general linear monoids. This talk is based on joint work in progress with Yifan Guo.

Venue: MCS2068

Nov 04 14:00 Yu-Chen Sun (University of Bristol):

Venue: MCS2068

Nov 11 14:00 Robin Bartlett (Glasgow University): Moduli spaces of mod p Galois representations and explicit equations for the crystalline locus of a fixed Hodge type.

Venue: MCS2068

Nov 25 14:00 Dante Luber (Queen Mary University of London): Matroid theory, algebra, and computation

Matroids combinatorially abstract independence properties of finite dimensional linear algebra. They have become ubiquitous in modern mathematics, and yield connections between graph theory, algebra, polyhedral geometry, optimization, and beyond. Special matroids capture the properties of point line arrangementments in complex 2-projective space. The moduli space of all line arrangements corresponding to a matroid is known as its realization space. After an introduction to matroid theory, we will discuss how we have used the OSCAR software system to study large datasets of matroids, isolating examples whose realization spaces have interesting algebro-geometric

Venue: MCS2068

Dec 02 14:00 Jay Taylor (University of Manchester):

Venue: MCS2068

Dec 09 14:00 Fredrik Stromberg (University of Nottingham):

Venue: MCS2068

• CPT Colloquium

Usual Venue: OC218

Contact: mohamed.anber@durham.ac.uk

For more information, see HERE.


No upcoming seminars have been scheduled (not unusual outside term time).

• Department Research Colloquium

Usual Venue: MCS0001

Contact: inaki.garcia-etxebarria@durham.ac.uk,sunil.chhita@durham.ac.uk

No upcoming seminars have been scheduled (not unusual outside term time).

• Distinguished and Public Lectures

Usual Venue: MCS0001

Contact: sabine.boegli@durham.ac.uk,alpar.r.meszaros@durham.ac.uk

No upcoming seminars have been scheduled (not unusual outside term time).

• Education and Pedagogy

Usual Venue: MCS3052

Contact: andrew.krause@durham.ac.uk

Oct 28 13:10 Litka Milian (Durham (Chemistry)): Listening to Student Voices: Disability and Inclusion in STEM

What does it really feel like to study chemistry at Durham as a disabled student? In this session, we will share insights from interviews with disabled students in the Chemistry Department, aiming to uncover the reasons behind the Awarding Gap in academic outcomes between disabled and non-disabled students. Through open conversations, students described barriers they face, sometimes as obvious as struggling to get into a lecture room, sometimes as subtle as feeling left out of group activities or not knowing where to find help. One student captured the frustration many feel, saying, “Sometimes it feels like the system wasn’t designed for people like me.” Another highlighted the problem of low expectations: “People often assume I need help with everything, but what I really need is for the environment to be accessible from the start.” These stories show that both attitudes and practical support need to change. Our project is a partnership between staff and student interns, who bring fresh perspectives and energy to the work. They have helped shape our questions, analyse the interviews, and will join us in presenting what we’ve learned. This collaborative approach reflects the principle of active pedagogy, where students are partners in shaping their own learning experience. We are still working on this project and are using what we’ve learned to write recommendations for future improvements. Our aim is to create more opportunities for students to share feedback, help shape solutions, and feel truly represented. By listening to student voices and acting on their ideas, we are putting inclusive learning design into practice, building a Chemistry Department and a STEM community where diversity is celebrated and every student has the chance to thrive, creating meaningful change.

Venue: MCS3052

• Gandalf

Usual Venue: MCS3070

Contact: daniel.n.disney@durham.ac.uk

No upcoming seminars have been scheduled (not unusual outside term time).

• Geometry and Topology

Usual Venue: MCS2068

Contact: fernando.galaz-garcia@durham.ac.uk

Oct 30 13:00 John Parker (Durham University): Real hyperbolic on the outside, complex hyperbolic on the inside (2)

The title of the talk is the title of a paper by Richard Schwartz (Inventiones 2003) where he constructs a complex hyperbolic orbifold whose boundary is homeomorphic to a closed real hyperbolic three-manifold. The fundamental group of the orbifold is an index two subgroup of a group generated by three reflections where certain products of the reflections have particular finite orders. The proof is by way of an explicit construction of a fundamental polyhedron. In these talks I will discuss a joint project with Yohei Komori and Makoto Sakuma where we take the first step to generalise Schwartz’s construction. Namely, we give a topological construction of a candidate fundamental domain, and thereby we are able to describe the topology of the boundary manifold explicitly in terms of the finite orders of the products of reflections. In particular, we are able to topologically identify Schwartz’s boundary manifold.

Venue: MCS2068

Nov 13 13:00 Pierre Will (Université Grenoble Alpes): TBA

TBA

Venue: MCS2068

Nov 20 13:00 Amy Herron (University of Bristol): Triangle Presentations in ~A_2 Bruhat-Tits Buildings

The 1-skeleton of an ~A_2 Bruhat-Tits building is isomorphic to the Cayley graph of an abstract group with relations coming from ”triangle presentations.” This abstract group either embeds into PGL(3, Fq((x))) or PGL(3, Qq), or else is exotic. Currently, the complete list of triangle presentations is only known for projective planes of orders q=2 or 3. However, one abstract group that embeds into PGL(3,Fq((x))) for any prime power q is known via the trace function corresponding to the finite field of order q^3. I found a new method to derive this group via perfect difference sets. This method demonstrates a previously unknown connection between difference sets and ~A_2 buildings. Moreover, this method makes the final computation of triangle presentations easier, which is computationally valuable for large q.

Venue: MCS2068

Nov 27 13:00 Yan Rybalko (University of Oslo): Generic regularity of the two-component Novikov system

In my talk I will discuss the generic regularity of the Cauchy problem for the two-component Novikov system. This system is integrable (i.e., it is bi-Hamiltonian, has a Lax pair, and an infinite number of conservation laws), and admits peakon solutions of the form p(t)exp(-|x-q(t)|). Another important feature of the Novikov system is the wave-breaking phenomenon: the solutions remain bounded for all times, but the slope can blow-up in finite time. In our work, we show that there exists an open dense subset of C^k regular initial data, such that the corresponding global solutions persist the regularity for all t,x except, possibly, a finite number of piecewise C^{k-1} characteristic curves. Our approach builds on the work by Bressan and Chen, which relies on transforming solutions from Eulerian variables to a new set of Bressan-Constantin variables, in which all possible singularities of the original solutions are resolved. Then, applying the Thom’s transversality theorem to the map related to the wave-breaking, we can construct an appropriate open dense subset of C^k regular initial data.

The talk is based upon the following papers:

K.H. Karlsen, Ya. Rybalko, "Generic regularity and a Lipschitz metric for the two-component Novikov system," in preparation. K.H. Karlsen, Ya. Rybalko, "Global semigroup of conservative weak solutions of the two-component Novikov equation," Nonlinear Analysis: Real World Applications 86, 104393 (2025). DOI: 10.1016/j.nonrwa.2025.104393.

Venue: MCS2068

Jan 22 13:00 Chunyang Hu (Durham University): TBA

TBA

Venue: MCS2068

Mar 06 13:00 Julian Scheuer (Goethe University Frankfurt): TBA

Venue: MCS2068

• HEP Journal Club

Usual Venue: MCS3070

Contact: mendel.t.nguyen@durham.ac.uk

No upcoming seminars have been scheduled (not unusual outside term time).

• HEP Lunchtime

Usual Venue: MCS0001

Contact: p.e.dorey@durham.ac.uk,enrico.andriolo@durham.ac.uk,tobias.p.hansen@durham.ac.uk

Oct 31 13:00 Max Velásquez Cotini Hutt (Imperial College London): Non-invertible Symmetries of 2d Non-Linear Sigma Models

Global symmetries can be generalised to transformations generated by topological operators, including cases in which this operator does not have an inverse. A family of such topological operators are related to dualities via the procedure of half-space gauging. I will discuss the construction of non-invertible defects based on T-duality in two dimensions, generalising the well-known case of the free compact boson to any Non-Linear Sigma Model with Wess-Zumino term which is T-dualisable. I will discuss how these symmetries can be used to constrain renormalisation group flows, and their fate in String Theory.

Venue: MCS0001

Nov 07 13:00 Stathis Vitouladitis (Université Libre de Bruxelles): Entanglement asymmetry and the limits of symmetry breaking

Entanglement asymmetry is a novel diagnostic of symmetry breaking, rooted in quantum information theory, particularly effective at capturing such effects within subsystems. In this talk, I will first introduce this observable, outline recent developments, and then generalise it to higher-form symmetries, with applications to topological phases and systems with continuous symmetry breaking. As a main application, I will establish an entropic Mermin-Wagner-Coleman theorem, valid for both 0-form and higher-form symmetries, and extended to subregions. These entropic theorems not only detect but also quantify symmetry breaking. In Goldstone phases (when allowed), the Rényi and entanglement asymmetries, increase monotonically with subregion size. Along the way, I will clarify subtleties in defining and computing entanglement asymmetry by Euclidean path integral methods and present standalone results on the entanglement entropy of gauge fields.

Venue: MCS0001

Nov 14 13:00 Christian Copetti (Oxford): TBA

Venue: MCS0001

Nov 21 13:00 Ida Zadeh (Southampton): TBA

Venue: MCS0001

Nov 28 13:00 Tim Meier (Santiago de Compostela): TBA

Venue: MCS0001

Dec 05 13:00 Marco Meineri (Torino): TBA

Venue: MCS0001

Dec 12 13:00 Sungwoo Hong (KAIST, Taejon): TBA

Venue: MCS0001

• Probability

Usual Venue: MCS2068

Contact: tyler.helmuth@durham.ac.uk,oliver.kelsey-tough@durham.ac.uk

Oct 30 14:00 Julie Tourniaire (Laboratoire de Mathématiques, Université de Franche-Comté): Stochastic neutral fractions and the effective population size

Population genetics aims to explain observed genetic diversity through past evolutionary forces. In the neutral setting, i.e., in the absence of natural selection and ecological constraints, diversity arises solely from demographic fluctuations. In this simplified framework, the allelic composition of a population converges, in the large-population limit, to the Wright–Fisher diffusion.

This Wright–Fisher model is a purely genetic model, and a key question is how ecological constraints (such as population structure) may influence genetic composition. In this context, the ‘effective population size’, defined as the size of a Wright–Fisher population experiencing the same level of genetic drift as the population under study, plays a central role.

In this talk, I will introduce a stochastic differential equation with an infinite decomposability property to model the dynamics of general structured populations. This property allows the population to be decomposed into an arbitrary number of neutral allelic components (or fractions). When demographic fluctuations are small, a fast–slow principle yields a general expression for the effective population size in structured settings.

This is joint work with R. Forien, E. Schertzer, and Z. Talyigas

Venue: MCS2068

Nov 06 14:00 William Da Silva (University of Vienna): The longest increasing subsequence of Brownian separable permutons

The Brownian separable permutons form a one-parameter family of permutons, which are the universal scaling limits of pattern-avoiding permutations. In this talk, we will be interested in the length of the longest increasing subsequence (LIS) in permutations of size n sampled from the Brownian permutons. We give an answer to the celebrated Ulam-Hammersley problem in this context: what is the behaviour of LIS as n goes to infinity? A significant portion of the talk will be dedicated to our motivation behind the problem, emphasising connections to various objects in probability and combinatorics, such as random decorated trees, random graphs, directed planar maps and SLE/LQG. The talk is based on joint work with Arka Adhikari, Jacopo Borga, Thomas Budzinski and Delphin Sénizergues.

Venue: MCS2068

Nov 20 14:00 PiNE (University of Edinburgh): No seminar — PiNE in Edinburgh.

PiNE will take place in Edinburgh, see https://www.maths.dur.ac.uk/PiNE/25-11-20/index.html. Accordingly we will not have a seminar this week.

Venue: MCS2068

• Pure Maths Colloquium

Usual Venue: MCS2068

Contact: michael.r.magee@durham.ac.uk

Nov 17 14:00 Pierre Will (Grenoble): TBA

Venue: MCS2068

Dec 01 14:00 Brian Petri (Jussieu): TBA

Venue: MCS2068

Dec 08 14:00 Stuart White (Oxford): TBA

Venue: MCS2068

• Spectra and Moduli

Usual Venue: MCS3070

Contact: joe.thomas@durham.ac.uk

No upcoming seminars have been scheduled (not unusual outside term time).

• Statistics

Usual Venue: MCS2068

Contact: hyeyoung.maeng@durham.ac.uk,andrew.iskauskas@durham.ac.uk

Oct 27 13:00 Ben Swallow (University of St. Andrews): Some recent developments in Bayesian Gaussian processes for non-linear systems in computational biology

Gaussian processes are a widely-used statistical tool for conducting non-parametric inference in computational biology. In this talk, I will outline a couple of recent projects where we have developed Bayesian computational approaches to approximating complex, non-linear dynamics in systems biology and infectious disease epidemiology, taking advantage of the analytical tractability of Gaussian processes. Firstly, I will discuss an extension to the linear noise approximation in high-dimensional, non-linear systems of chemical kinetics, embedded within a Bayesian MCMC framework for accurate parameter inference and uncertainty quantification. The approach is applied to cell-signalling and circadian clock systems of up to 20 variables. Secondly, I will describe an approach to modelling spatio-temporally indexed data on notifiable diseases in England, using software packages that can interact with tensorflow probability. The approach enables a relatively straightforward implementation on GPUs with significant speed increase over standard CPU calculations, whilst still allowing asymptotically exact inference and uncertainty quantification. Long-term temporal accuracy is maintained in both approaches.

Venue: MCS2068

Nov 03 13:00 Sam Livingstone (UCL):

Venue: MCS2068

Dec 01 13:00 Markus Rau (Newcastle):

Venue: MCS2068

• Stats4Grads

Contact: adam.stone2@durham.ac.uk

No upcoming seminars have been scheduled (not unusual outside term time).

Special Series

These link to some of the special events hosted by the Department:


• [LMS|EPSRC] Durham Symposia (from 1974)
• Collingwood Lectures (from 1984)